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      PEG制備方法7-醫用可生物降解PLGA-PEG-MAL的合成

      時間:2019-07-24 10:47:36       瀏覽:1492

      PEG制備方法7-醫用可生物降解PLGA-PEG-MAL的合成


      這類共聚物的應用報道近年來越來越多。由于聚醚的存在, 使共聚物具有親水性和柔軟性,在藥物控制釋放中可作為表面活性劑, 微球表面修飾劑, 也可用于制備載藥微球, 載藥毫微球等。

      目前研究得較多的為聚乙二醇2聚酯及聚乙二醇2聚氨基酸共聚物。聚乙二醇2聚酯共聚物一般用聚乙二醇與環狀內酯開環共聚制備以聚乙二醇2聚乳酸共聚物的制備示例如下[ 39 ] (22) :

      聚乙二醇2聚氨基酸共聚物一般用聚乙二醇胺與環狀氨基酸氮酸酐開環共聚制備, 以聚乙二醇2聚芐酯谷氨酸共聚物的制備, 示例如下[ 40 ] (23) :

      產品列表:

      PLGA-PEG-NH2,PLGA-PEG-Amine 

      PLGA-PEG-COOH,PLGA-PEG-carboxyl

      PLGA-PEG-MAL,PLGA-PEG-Maleimide

      PLGA-PEG-NHS 

      PLGA-PEG-N3,PLGA-PEG-azide

      PLGA-PEG-Alkyne

      PLGA-PEG-SH,PLGA-PEG-Thiol

      PLGA-PEG-Biotin 

      PLGA-PEG-CHO,PLGA-PEG-aldehyde

      PLGA-PEG-OPSS

      PLGA-PEG-OH/hydroxyl

      PLGA-PEG-Hydrazide/ HZ

      PLGA-PEG-Silane

      PLGA-PEG-Acrylates (ACRL)

      PLGA-PEG-Lipoic acid/LA

      PLGA-PEG-Tosyl,PLGA-PEG-Tosylate

      PLGA-PEG-Acetylthio

      PLGA-PEG-Aminooxy

      PLGA-PEG-Nitrophenyl Carbonates (NPC)

      PLGA-PEG-SAS, SC, SCM, SG, SS, SVA

      PLGA-PEG-Epoxides (EPOX)

      PLGA-PEG-Valeric Acids (VA)

      PLGA-PEG-Acrylamide

      PLGA-PEG-Bromide(Br)

      PLGA-PEG-Vinylsulfone(VS)

      PLGA-PEG-Methacrylate (MA)

      PLGA-PEG-Iodoacetate(IA)

      PLGA-PEG-Chloride

      PLGA-PEG-DBCO

      PLGA-PEG-TCO

      PLGA-PEG-TZ,PLGA-PEG-Tetrazine

      PLGA-PEG-Folate ,PLGA-PEG-FA/folic acid 

      PLGA-PEG-Multi-Arms (4 arm 8arm)

      PLGA-PEG-Protected Amines (FMOC, tBOC)

      PLGA-PEG-CHEMS

       

       

      PCL-PEG-NH2,PCL-PEG-Amine 

      PCL-PEG-COOH,PCL-PEG-carboxyl

      PCL-PEG-MAL,PCL-PEG-Maleimide

      PCL-PEG-NHS 

      PCL-PEG-N3 PCL-PEG-azide

      PCL-PEG-Alkyne

      PCL-PEG-SH ,PCL-PEG-Thiol

      PCL-PEG-Biotin 

      PCL-PEG-CHO, PCL-PEG-aldehyde

      PCL-PEG-OPSS

      PCL-PEG-OH /hydroxyl

      PCL-PEG-Hydrazide, PCL-PEG-HZ

      PCL-PEG-Silane

      PCL-PEG-Acrylates (ACRL)

      PCL-PEG-Lipoic acid LA

      PCL-PEG-Tosyl,Tosylate

      PCL-PEG-Acetylthio

      PCL-PEG-Aminooxy

      PCL-PEG-Nitrophenyl Carbonates (NPC)

      PCL-PEG-SAS, SC, SCM, SG, SS, SVA

      PCL-PEG-Epoxides (EPOX)

      PCL-PEG-Valeric Acids (VA)

      PCL-PEG-Acrylamide

      PCL-PEG-Bromide(Br)

      PCL-PEG-Vinylsulfone(VS)

      PCL-PEG-Methacrylate (MA)

      PCL-PEG-Iodoacetate(IA)

      PCL-PEG-Chloride

      PCL-PEG-DBCO

      PCL-PEG-TCO

      PCL-PEG-TZ/Tetrazine

      PCL-PEG-Folate ,FA, folic acid 

      PCL-PEG-Multi-Arms (4 arm 8arm)

      PCL-PEG-Protected Amines (FMOC, tBOC)

      PCL-PEG-CHEMS

       

      PLA-PEG-NH2,PLA-PEG-Amine 

      PLA-PEG-COOH,PLA-PEG-carboxyl

      PLA-PEG-MAL,PLA-PEG-Maleimide

      PLA-PEG-NHS 

      PLA-PEG-N3 PLA-PEG-azide

      PLA-PEG-Alkyne

      PLA-PEG-SH ,PLA -PEG-Thiol

      PLA-PEG-Biotin 

      PLA-PEG-CHO, PLA -PEG-aldehyde

      PLA-PEG-OPSS

      PLA-PEG-OH /hydroxyl

      PLA-PEG-Hydrazide, PLA -PEG-HZ

      PLA-PEG-Silane

      PLA-PEG-Acrylates (ACRL)

      PLA-PEG-Lipoic acid LA

      PLA-PEG-Tosyl,Tosylate

      PLA-PEG-Acetylthio

      PLA-PEG-Aminooxy

      PLA-PEG-Nitrophenyl Carbonates (NPC)

      PLA-PEG-SAS, SC, SCM, SG, SS, SVA

      PLA-PEG-Epoxides (EPOX)

      PLA-PEG-Valeric Acids (VA)

      PLA-PEG-Acrylamide

      PLA-PEG-Bromide(Br)

      PLA-PEG-Vinylsulfone(VS)

      PLA-PEG-Methacrylate (MA)

      PLA-PEG-Iodoacetate(IA)

      PLA-PEG-Chloride

      PLA-PEG-DBCO

      PLA-PEG-TCO

      PLA-PEG-TZ,PLA-PEG-Tetrazine

      PLA-PEG-Folate,PLA-PEG-FA, folic acid 

      PLA-PEG-Multi-Arms (4 arm 8arm)

      PLA-PEG-Protected Amines (FMOC, tBOC)

      PLA-PEG-CHEMS

      PAA-PEG-NH2,PAA-PEG-Amine 

      PAA-PEG-COOH,PAA-PEG-carboxyl

      PAA-PEG-MAL,PAA-PEG-Maleimide

      PAA-PEG-NHS 

      PAA-PEG-N3 PAA-PEG-azide

      PAA-PEG-Alkyne

      PAA-PEG-SH ,PAA-PEG-Thiol

      PAA-PEG-Biotin 

      PAA-PEG-CHO, PAA-PEG-aldehyde

      PAA-PEG-OPSS

      PAA-PEG-OH /hydroxyl

      PAA-PEG-Hydrazide, PAA-PEG-HZ

      PAA-PEG-Silane

      PAA-PEG-Acrylates (ACRL)

      PAA-PEG-Lipoic acid LA

      PAA-PEG-Tosyl,Tosylate

      PAA-PEG-Acetylthio

      PAA-PEG-Aminooxy

      PAA-PEG-Nitrophenyl Carbonates (NPC)

      PAA-PEG-SAS, SC, SCM, SG, SS, SVA

      PAA-PEG-Epoxides (EPOX)

      PAA-PEG-Valeric Acids (VA)

      PAA-PEG-Acrylamide

      PAA-PEG-Bromide(Br)

      PAA-PEG-Vinylsulfone(VS)

      PAA-PEG-Methacrylate (MA)

      PAA-PEG-Iodoacetate(IA)

      PAA-PEG-Chloride

      PAA-PEG-DBCO

      PAA-PEG-TCO

      PAA-PEG-TZ/Tetrazine

      PAA-PEG-Folate ,PAA-PEG-FA, folic acid 

      PAA-PEG-Multi-Arms (4 arm 8arm)

      PAA-PEG-Protected Amines (FMOC, tBOC)

      PAA-PEG-CHEMS

       


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